Effect of Antihistamines (Fexofenadineand Chlopheneramine) on activity some hepatical enzymes by using fertilized hens eggs embryos as a model

The aim of the present study was to investigate effect antihistamines(Chlorpheneramineand Fexofenadine) on (alkaline phosphatase, aspartate amino transpherase and alanine transferase) in tissue fertilized hens eggs embryos as indicator damage. injection hen's with antihistamines Fexofenadine at 12th day incubation doses (0,5,0,1mg/ egginto air sell)after 24 hour treatment induce significantly decrease tissues activity alkaline phosphatase (ALP),aspartate (AST) transferase (ALT) compared control group adose-dependent manner.Ingection Chlorpheneramineat dose (0,5,0,1 mg/egginto cell)induce ofalkaline group, but no significant transpharase(ALT)at dose(0,5,0,1mg/egg) group.Compare ChlorpheneramineandFexofenadine some biochemical parameters, chlorpheneramine cause significan intissues (ALP) larger than which terated withfexofenadine same dose, also treated fexofenadine dose.We conclode hasharmful effects tissueschick embryorepresented by changes parameter its consider a marker for damage this